Long–term Neurodevelopment outcomes to Prenatal Antipsychotic Medication Exposure: Systemic Review

Introduction Peak incidence for many psychiatric disorders occurs in reproductive years. We don’t have FDA-approved drugs or clinical guidelines. The main cause of pharmacological suspension pregnancy is the lack knowledge their effects on product. Gathering information this regard becomes crucial so we can avoid relapses exacerbation Objectives Describe neurodevelopmental children ≥ 6 months exposed to antipsychotics prenatally. Methods PROSPERO-CRD42020170314. Using MeSH terms 5 databases, without language and time restriction, obtaining n=3932. After review exclusion n=24 were obtained qualitative review. (Figure 1). Results Of 20 case reports 4 had more ambivalence results (Table In cohort studies, exposure may short-term delay at but no significant difference 12 2). Table 2 Study N Antipsychotic Months Conclusion using evaluation Imaz et al. Front. Pharmacol.2018; 9:264 1 Risperdal Clozapine 72 Abnormal memory, attention/executive, hyperactivity 32 Normal 18 Burt Am J Psychiatry 2010; 167:892-897 Olanzapine 12,18, 22,29 motor 22 normal 29 Kirchheiner Pharmacopsych 2000; 33:78-80 7,11 7 11 Mendhekar Neuropsychiatry Clin Neurosci 2007; 19:2 years 3 clinimetry Shao Plos ONE, 2015; 10(4),1-9 63 Risperidone Quetiapine 6,12 BSID-III Adaptive behavior score lower clozapine group No Johnson Arch Gen Psychiatry2012; 69(8), 787-794 Haloperidol SGA* INFANIB Lower scores with SGA then Peng Psychopharmacology 2013; 228(4), 577-584 76 Sulpiride socio-emotional adaptive Petersen BMJ 2016; 5(6), 1-9 290 FGA+SGA** More disorder that those who didn’t take antipsychotics. Image: Conclusions Most are reports, hence importance collecting information, not ignoring it due methodological rigor. intent conclude prenatal doesn’t long-term effects, rather documenting available evidence contributing an informed decision. Disclosure Interest None Declared